Article
Common variation in NCAN, a risk factor for bipolar disorder and schizophrenia, influences local cortical folding in schizophrenia.
Psychological medicine - 1 Mar 2014
Schultz C C, Mühleisen T W, Nenadic I, Koch K, Wagner G, Schachtzabel C, Siedek F, Nöthen M M, Rietschel M, Deufel T, Kiehntopf M, Cichon S, Reichenbach J R, Sauer H, Schlösser R G M
Abstract excerpt
BACKGROUND: Recent studies have provided strong evidence that variation in the gene neurocan (NCAN, rs1064395) is a common risk factor for bipolar disorder (BD) and schizophrenia. However, the possible relevance of NCAN variation to disease mechanisms in the human brain has not yet been explored. Thus, to identify a putative pathomechanism, we tested whether the risk allele has an influence on cortical thickness...
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