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Article

Genetic and in silico analysis show a role of SMAD3 on recurrent pregnancy loss.

Human fertility (Cambridge, England) - 1 Oct 2022

Matheus Bremm João, Michels Marcus, Duarte Rengel Bruna, Gomes Flavia Gobetti, Fraga Lucas Rosa, Sanseverino Maria Teresa Vieira

Abstract excerpt

Recurrent pregnancy loss (RPL) is one of the most common reproductive failures affecting 1-5% of couples. Smad3 is an effector of signalling of the Transforming Growth Factors-β superfamily (TGF-β), regulating the transcription of several target genes of these cytokines. The objective of this study was to evaluate the influence of a variant on SMAD3 (rs17293443) in RPL. A case-control study was carried out with...

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Identifiers

PMID: 34030553
DOI: 10.1080/14647273.2021.1922764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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