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Article

NEK8 links the ATR-regulated replication stress response and S phase CDK activity to renal ciliopathies.

Molecular cell - 22 Aug 2013

Choi Hyo Jei Claudia, Lin Jia-Ren, Vannier Jean-Baptiste, Slaats Gisela G, Kile Andrew C, Paulsen Renee D, Manning Danielle K, Beier David R, Giles Rachel H, Boulton Simon J, Cimprich Karlene A

Abstract excerpt

Renal ciliopathies are a leading cause of kidney failure, but their exact etiology is poorly understood. NEK8/NPHP9 is a ciliary kinase associated with two renal ciliopathies in humans and mice, nephronophthisis (NPHP) and polycystic kidney disease. Here, we identify NEK8 as a key effector of the ATR-mediated replication stress response. Cells lacking NEK8 form spontaneous DNA double-strand breaks (DSBs) that...

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Source

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Identifiers

PMID: 23973373
DOI: 10.1016/j.molcel.2013.08.006
PMCID: PMC3790667

Genes

NEK8
ATR

Provenance

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NEK8 links the ATR-regulated replication stress response and S phase CDK activity to renal ciliopathies.PMID 23973373Read ↗

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