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Article

Association of genetic variants in CYP3A5, DRD2 and NK1R with opioid overdose.

Chemico-biological interactions - 1 Nov 2024

Lambert Joshua, Petrovitch Dan, Himes Katie P, Freiermuth Caroline E, Braun Robert S, Brown Jennifer L, Bischof Jason J, Lyons Michael S, Punches Brittany E, Littlefield Andrew K, Kisor David F, Sprague Jon E

Abstract excerpt

In 2023, 3651 Ohioans died because of an opioid overdose. Of those opioid overdoses, 3579 (98%) of which were attributed to fentanyl. We evaluated the association between 180 candidate single nucleotide polymorphisms (SNPs) and self-reported, nonfatal opioid overdose history from a prospective sample of 1301 adult patients (≥18 years of age) seen in three urban emergency departments in Ohio. Candidate SNPs...

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Share to Analgesics, Opioid
Share to Cytochrome P-450 CYP3A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Receptors, Dopamine D2

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Source

Identifiers

PMID: 39265714
DOI: 10.1016/j.cbi.2024.111242

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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