Article
Scoping review of associations between cytochrome P450 3A4/5 single nucleotide polymorphisms and risk factors for fentanyl overdose.
Pharmacogenomics - 1 Jan 2025
Petrovitch Dan, Himes Katie P, Bischof Jason J, Braun Robert S, Brown Jennifer L, Eleda Isaiah C, Freiermuth Caroline E, Gu Shaopeng, Hall O Trent, Johnson Julie A, Kisor David F, Lambert Joshua W, Lyons Michael S, Maloney Morgan V, Punches Brittany E, Quarles Emma, Littlefield Andrew K, Sprague Jon E
Abstract excerpt
INTRODUCTION: Fentanyl overdose is a public health crisis in the United States, as fentanyl was implicated in nearly 70% of drug overdose deaths in 2023. To provide insight into genetic factors that may influence risk of fentanyl overdose, we conducted a scoping review of associations between cytochrome P450 3A4 (CYP3A4) and 3A5 (CYP3A5) genetic variants and relevant phenotypes. AREAS COVERED: We searched...
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