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Article

Overexpression of Shox2 leads to congenital dysplasia of the temporomandibular joint in mice.

International journal of molecular sciences - 24 Jul 2014

Li Xihai, Liang Wenna, Ye Hongzhi, Weng Xiaping, Liu Fayuan, Liu Xianxiang

Abstract excerpt

Our previous study reported that inactivation of Shox2 led to dysplasia and ankylosis of the temporomandibular joint (TMJ), and that replacing Shox2 with human Shox partially rescued the phenotype with a prematurely worn out articular disc. However, the mechanisms of Shox2 activity in TMJ development remain to be elucidated. In this study, we investigated the molecular and cellular basis for the congenital...

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Identifiers

PMID: 25062348
DOI: 10.3390/ijms150813135
PMCID: PMC4159784

Genes

MMP13
MMP9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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