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Article

FGFR3 is a target of the homeobox transcription factor SHOX in limb development.

Human molecular genetics - 15 Apr 2011

Decker Eva, Durand Claudia, Bender Sebastian, Rödelsperger Christian, Glaser Anne, Hecht Jochen, Schneider Katja U, Rappold Gudrun

Abstract excerpt

The short stature homeobox gene SHOX encodes a transcription factor which is important for normal limb development. In humans, SHOX deficiency has been associated with various short stature syndromes including Leri-Weill dyschondrosteosis (LWD), Langer mesomelic dysplasia and Turner syndrome as w...

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Source

Identifiers

PMID: 21273290
DOI: 10.1093/hmg/ddr030

Genes

SHOX
FGFR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21273290-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FGFR3 is a target of the homeobox transcription factor SHOX in limb development.PMID 21273290Read ↗

New roles of SHOX as regulator of target genes.Semantic proximity Read ↗

Long-range conserved non-coding SHOX sequences regulate expression in developing chicken limb and are associated with short stature phenotypes in human patients.Semantic proximity Read ↗

A mouse model for human short-stature syndromes identifies Shox2 as an upstream regulator of Runx2 during long-bone development.Semantic proximity Read ↗

The short stature homeobox gene SHOX is involved in skeletal abnormalities in Turner syndrome.Semantic proximity Read ↗

SHOX at a glance: from gene to protein.Semantic proximity Read ↗

Shox2 is required for chondrocyte proliferation and maturation in proximal limb skeleton.Semantic proximity Read ↗

SHOX in short stature syndromes.Semantic proximity Read ↗

NPPB and ACAN, two novel SHOX2 transcription targets implicated in skeletal development.Semantic proximity Read ↗

Clinical and genetic spectrum of SHOX deficiency: phenotypic heterogeneity and the "Jumping SHOX" phenomenon.Semantic proximity Read ↗

Short stature and dysmorphology associated with defects in the SHOX gene.Semantic proximity Read ↗

Detection of SHOX Gene Variations in Patients with Skeletal Abnormalities with or without Short StatureSemantic proximity Read ↗

The SHOX region and its mutations.Semantic proximity Read ↗

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