Article

Shoc2 controls ERK1/2-driven neural crest development by balancing components of the extracellular matrix

2022-06-14

Abstract excerpt

<h4>ABSTRACT</h4> The extracellular signal-regulated kinase (ERK1/2) pathway is essential in embryonic development. The scaffold protein Shoc2 is a critical modulator of ERK1/2 signals, and mutations in the shoc2 gene lead to the human developmental disease known as Noonan-like syndrome with loose anagen hair (NSLH). The loss of Shoc2 and the shoc2 NSLH-causing mutations affect the tissues of neural crest (NC)...

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Literature Corpus work: dc1e4770-4ac7-5b1c-bbde-d5b2bf4993e7
DOI: 10.1101/2022.06.13.495941

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