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Article

The role of oxidoreductases in determining the function of the neisserial lipid A phosphoethanolamine transferase required for resistance to polymyxin.

PloS one - 1 Jan 2014

Piek Susannah, Wang Zhirui, Ganguly Jhuma, Lakey Adam M, Bartley Stephanie N, Mowlaboccus Shakeel, Anandan Anandhi, Stubbs Keith A, Scanlon Martin J, Vrielink Alice, Azadi Parastoo, Carlson Russell W, Kahler Charlene M

Abstract excerpt

The decoration of the lipid A headgroups of the lipooligosaccharide (LOS) by the LOS phosphoethanolamine (PEA) transferase (LptA) in Neisseria spp. is central for resistance to polymyxin. The structure of the globular domain of LptA shows that the protein has five disulphide bonds, indicating that it is a potential substrate of the protein oxidation pathway in the bacterial periplasm. When neisserial LptA was...

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Identifiers

PMID: 25215579
DOI: 10.1371/journal.pone.0106513
PMCID: PMC4162559

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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