Article
Characterization of galacturonosyl transferase genes rgtA, rgtB, rgtC, rgtD, and rgtE responsible for lipopolysaccharide synthesis in nitrogen-fixing endosymbiont Rhizobium leguminosarum: lipopolysaccharide core and lipid galacturonosyl residues confer membrane stability.
The Journal of biological chemistry - 6 Jan 2012
Brown Dusty B, Forsberg L Scott, Kannenberg Elmar L, Carlson Russell W
Abstract excerpt
Rhizobium lipopolysaccharide (LPS) contains four terminally linked galacturonic acid (GalA) residues; one attached to the lipid A and three attached to the core oligosaccharide moiety. Attachment of the GalA residues requires the lipid donor dodecaprenyl-phosphate GalA (Dod-P-GalA), which is synthesized by the GalA transferase RgtE reported here. The galacturonosyl transferases RgtA, -B, and -C utilize Dod-P-GalA...
Topics
- Anti-Bacterial Agents
- Bacterial Proteins
- Cell Membrane
- Drug Resistance, Bacterial
- Genes, Bacterial
- Glucuronosyltransferase
- Lipopolysaccharides
- Mutagenesis, Insertional
- Mutation