Article
Genetic linkage analysis to identify a gene required for the addition of phosphoethanolamine to meningococcal lipopolysaccharide.
Gene - 6 Feb 2002
Tang Christoph M, Stroud Dave, Mackinnon Fiona, Makepeace Katherine, Plested Joyce, Moxon E Richard, Chalmers Ronald
Abstract excerpt
Lipopolysaccharide (LPS) is important for the virulence of Neisseria meningitidis, and is the target of immune responses. We took advantage of a monoclonal antibody (Mab B5) that recognises phosphoethanolamine (PEtn) attached to the inner core of meningococcal LPS to identify genes required for the addition of PEtn to LPS. Insertional mutants that lost Mab B5 reactivity were isolated and characterised, but failed...
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