Article
Characterization of Two Novel Lipopolysaccharide Phosphoethanolamine Transferases in Pasteurella multocida and Their Role in Resistance to Cathelicidin-2.
Infection and immunity - 1 Nov 2017
Harper Marina, Wright Amy, St Michael Frank, Li Jianjun, Deveson Lucas Deanna, Ford Mark, Adler Ben, Cox Andrew D, Boyce John D
Abstract excerpt
The lipopolysaccharide (LPS) produced by the Gram-negative bacterial pathogen Pasteurella multocida has phosphoethanolamine (PEtn) residues attached to lipid A, 3-deoxy-d-manno-octulosonic acid (Kdo), heptose, and galactose. In this report, we show that PEtn is transferred to lipid A by the P. multocida EptA homologue, PetL, and is transferred to galactose by a novel PEtn transferase that is unique to P....
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