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Article

Endotoxin of Neisseria meningitidis composed only of intact lipid A: inactivation of the meningococcal 3-deoxy-D-manno-octulosonic acid transferase.

Journal of bacteriology - 1 May 2002

Tzeng Yih-Ling, Datta Anup, Kolli V Kumar, Carlson Russell W, Stephens David S

Abstract excerpt

Lipopolysaccharide, lipooligosaccharide (LOS), or endotoxin is important in bacterial survival and the pathogenesis of gram-negative bacteria. A necessary step in endotoxin biosynthesis is 3-deoxy-D-manno-octulosonic acid (Kdo) glycosylation of lipid A, catalyzed by the Kdo transferase KdtA (WaaA). In enteric gram-negative bacteria, this step is essential for survival. A nonpolar kdtA::aphA-3 mutation was created...

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Identifiers

PMID: 11948150
DOI: 10.1128/JB.184.9.2379-2388.2002
PMCID: PMC134985

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Source receipt: pubmed, retrieved 7 Sept 2026.

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