Article
Identification of a gene (lpt-3) required for the addition of phosphoethanolamine to the lipopolysaccharide inner core of Neisseria meningitidis and its role in mediating susceptibility to bactericidal killing and opsonophagocytosis.
Molecular microbiology - 1 Feb 2002
Mackinnon Fiona G, Cox Andrew D, Plested Joyce S, Tang Christoph M, Makepeace Katherine, Coull Philip A, Wright J Claire, Chalmers Ronald, Hood Derek W, Richards James C, Moxon E Richard
Abstract excerpt
We have identified a gene, lpt-3, that is required for the addition of phosphoethanolamine to the 3-position (PEtn-3) on the beta-chain heptose (HepII) of the inner core lipopolysaccharide (LPS) of Neisseria meningitidis (Nm). The presence of this PEtn-3 substituent is characteristic of the LPS of a majority ( approximately 70%) of hypervirulent Nm strains, irrespective of capsular serogroup, and is required for...
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