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Article

Phosphoethanolamine Transferase LptA in Haemophilus ducreyi Modifies Lipid A and Contributes to Human Defensin Resistance In Vitro.

PloS one - 1 Jan 2015

Trombley Michael P, Post Deborah M B, Rinker Sherri D, Reinders Lorri M, Fortney Kate R, Zwickl Beth W, Janowicz Diane M, Baye Fitsum M, Katz Barry P, Spinola Stanley M, Bauer Margaret E

Abstract excerpt

Haemophilus ducreyi resists the cytotoxic effects of human antimicrobial peptides (APs), including α-defensins, β-defensins, and the cathelicidin LL-37. Resistance to LL-37, mediated by the sensitive to antimicrobial peptide (Sap) transporter, is required for H. ducreyi virulence in humans. Cationic APs are attracted to the negatively charged bacterial cell surface. In other gram-negative bacteria, modification...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25902140
DOI: 10.1371/journal.pone.0124373
PMCID: PMC4406763

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