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PAD2 Overexpression in Transgenic Mice Promotes Spontaneous Skin Neoplasia

11 Sept 2014

Abstract excerpt

Peptidylarginine deiminase 2 (PAD2/PADI2) has been implicated in various inflammatory diseases and, more recently, cancer. The goal of this study was to test the hypothesis that PAD2 promotes oncogenesis using a transgenic mouse model. We found that about 37% of transgenic mice overexpressing human FLAG-PAD2 downstream of the MMTV-LTR promoter develop spontaneous neoplastic skin lesions. Molecular and...

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PMID: 25213324
DOI: 10.1158/0008-5472.can-14-0749

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