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Article

The role of PIM1/PIM2 kinases in tumors of the male reproductive system

30 Nov 2016

Abstract excerpt

The PIM family of serine/threonine kinases has three highly conserved isoforms (PIM1, PIM2 and PIM3). PIM proteins are regulated through transcription and stability by JAK/STAT pathways and are overexpressed in hematological malignancies and solid tumors. The PIM kinases possess weak oncogenic abilities, but enhance other genes or chemical carcinogens to induce tumors. We generated conditional transgenic mice...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27901106
DOI: 10.1038/srep38079

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