Article
Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.
Nature communications - 27 Jul 2018
Xue Angli, Wu Yang, Zhu Zhihong, Zhang Futao, Kemper Kathryn E, Zheng Zhili, Yengo Loic, Lloyd-Jones Luke R, Sidorenko Julia, Wu Yeda, McRae Allan F, Visscher Peter M, Zeng Jian, Yang Jian
Abstract excerpt
Type 2 diabetes (T2D) is a very common disease in humans. Here we conduct a meta-analysis of genome-wide association studies (GWAS) with ~16 million genetic variants in 62,892 T2D cases and 596,424 controls of European ancestry. We identify 139 common and 4 rare variants associated with T2D, 42 of which (39 common and 3 rare variants) are independent of the known variants. Integration of the gene expression data...
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