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Article

Genetic variants in PLG, LPA, and SIGLEC 14 as well as smoking contribute to plasma plasminogen levels.

Blood - 13 Nov 2014

Ma Qianyi, Ozel Ayse B, Ramdas Shweta, McGee Beth, Khoriaty Rami, Siemieniak David, Li Hong-Dong, Guan Yuanfang, Brody Lawrence C, Mills James L, Molloy Anne M, Ginsburg David, Li Jun Z, Desch Karl C

Abstract excerpt

Plasminogen is the precursor of the serine protease plasmin, a central enzyme of the fibrinolytic system. Plasma levels of plasminogen vary by almost 2-fold among healthy individuals, yet little is known about its heritability or genetic determinants in the general population. In order to identify genetic factors affecting the natural variation of plasminogen levels, we performed a genome-wide association study...

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Source

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Identifiers

PMID: 25208887
DOI: 10.1182/blood-2014-03-560086
PMCID: PMC4231423

Genes

PLG
LPA
SIGLEC14

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic variants in PLG, LPA, and SIGLEC 14 as well as smoking contribute to plasma plasminogen levels.PMID 25208887Read ↗

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