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[Compound heterozygous plasminogen mutations causing hereditary plasminogen deficiency: a family study and mechanistic analysis].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi - 14 Jan 2026

Lu Y F, Yu D D, Xu Q Y, Wang F J, Qin L Y, Wang M S, Yang L L

Abstract excerpt

Objective: To investigate the molecular mechanisms underlying compound heterozygous mutations in a patient with hereditary plasminogen (PLG) deficiency. Methods: The proband presented to the First Affiliated Hospital of Wenzhou Medical University with a 2-day history of left-sided limb weakness. Plasminogen activity (PLG∶A) and plasminogen antigen (PLG∶Ag) were measured by chromogenic substrate and enzyme-linked...

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Identifiers

PMID: 41663186
DOI: 10.3760/cma.j.cn121090-20250317-00137
PMCID: PMC13463339

Genes

PLG

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