Article
The Unravelling of the Genetic Architecture of Plasminogen Deficiency and its Relation to Thrombotic Disease.
Scientific reports - 15 Dec 2016
Martin-Fernandez Laura, Marco Pascual, Corrales Irene, Pérez Raquel, Ramírez Lorena, López Sonia, Vidal Francisco, Soria José Manuel
Abstract excerpt
Although plasminogen is a key protein in fibrinolysis and several mutations in the plasminogen gene (PLG) have been identified that result in plasminogen deficiency, there are conflicting reports to associate it with the risk of thrombosis. Our aim was to unravel the genetic architecture of PLG in families with plasminogen deficiency and its relationship with spontaneous thrombotic events in these families. A...
Topics
- Adolescent
- Adult
- Aged
- Female
- Genetic Variation
- High-Throughput Nucleotide Sequencing
- Humans
- Male
- Middle Aged
- Phenotype
- Plasminogen
- Polymorphism, Genetic
- Risk Factors
- Sequence Analysis, DNA