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Article

Development and validation of an oligonucleotide ligation assay to detect lamivudine resistance in hepatitis B virus.

Journal of virological methods - 1 Jul 2016

Beck Ingrid A, Payant Rachel, Ngo-Giang-Huong Nicole, Khamduang Woottichai, Laomanit Laddawan, Jourdain Gonzague, Frenkel Lisa M

Abstract excerpt

Treatment of chronic hepatitis B virus (HBV) infection with lamivudine-monotherapy rapidly selects mutant variants in a high proportion of individuals. Monitoring lamivudine resistance by consensus sequencing is costly and insensitive for detection of minority variants. An oligonucleotide ligation assay (OLA) for HBV lamivudine-resistance was developed and compared to consensus sequencing. Both assays detected...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 27025356
DOI: 10.1016/j.jviromet.2016.03.014
PMCID: PMC5074383

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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