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Article

Investigation of transcription factor Ndt80 affinity differences for wild type and mutant DNA: a molecular dynamics study.

Proteins - 1 Nov 2008

Hart Katarina, Nilsson Lennart

Abstract excerpt

Molecular dynamics simulations and free energy calculations have been performed on the transcription factor Ndt80 either in complex with the native DNA sequence or with a mutant DNA with a switched central base pair, C5-G5' to G5-C5'. This mutant has been shown to have a 100-fold decrease in binding affinity of Ndt80, and in this study we explain this both structurally and energetically. The major interactions...

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Identifiers

PMID: 18433057
DOI: 10.1002/prot.22062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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