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Article

Correlated motions and interactions at the onset of the DNA-induced partial unfolding of Ets-1.

Biophysical journal - 18 Feb 2009

Kamberaj Hiqmet, van der Vaart Arjan

Abstract excerpt

The binding of the Ets-1 transcription factor to its target DNA sequence is characterized by a highly unusual conformational change consisting of the unfolding of inhibitory helix 1 (HI-1). To probe the interactions that lead to this unfolding, we performed molecular dynamics simulations of the f...

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Identifiers

PMID: 19217849
DOI: 10.1016/j.bpj.2008.11.019
PMCID: PMC2717251

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19217849-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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