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Article

Meta-analysis of Complex Diseases at Gene Level with Generalized Functional Linear Models.

Genetics - 1 Feb 2016

Fan Ruzong, Wang Yifan, Chiu Chi-Yang, Chen Wei, Ren Haobo, Li Yun, Boehnke Michael, Amos Christopher I, Moore Jason H, Xiong Momiao

Abstract excerpt

We developed generalized functional linear models (GFLMs) to perform a meta-analysis of multiple case-control studies to evaluate the relationship of genetic data to dichotomous traits adjusting for covariates. Unlike the previously developed meta-analysis for sequence kernel association tests (MetaSKATs), which are based on mixed-effect models to make the contributions of major gene loci random, GFLMs are fixed...

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Identifiers

PMID: 26715663
DOI: 10.1534/genetics.115.180869
PMCID: PMC4788228

Genes

HHEX
HMGA2
MAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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