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Article

[Effect of the targeted mutation of sorting motifs on the localization of porcine Ia-associated invariant chain].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology - 1 Sept 2014

Liu Wei, Xu Fazhi

Abstract excerpt

OBJECTIVE: To investigate the effect of amino acids around two Leu-based motifs (Leu 7/Ile 8 and Met 16/Leu 17) in the cytosolic tail of porcine Ia-associated invariant chain (Ii) on endomembrane system positioning function. METHODS: At first, two Leu-based motifs and amino acids around motifs were mutated through site-directed mutagenesis of the megaprimer PCR method, and the mutant genes were ligated to the...

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PMID: 25200155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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