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Article

Triplet-Based Codon Organization Optimizes the Impact of Synonymous Mutation on Nucleic Acid Molecular Dynamics.

Journal of molecular evolution - 1 Feb 2018

Babbitt Gregory A, Coppola Erin E, Mortensen Jamie S, Ekeren Patrick X, Viola Cosmo, Goldblatt Dallan, Hudson André O

Abstract excerpt

Since the elucidation of the genetic code almost 50 years ago, many nonrandom aspects of its codon organization remain only partly resolved. Here, we investigate the recent hypothesis of 'dual-use' codons which proposes that in addition to allowing adjustment of codon optimization to tRNA abundance, the degeneracy in the triplet-based genetic code also multiplexes information regarding DNA's helical shape and...

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Identifiers

PMID: 29344693
DOI: 10.1007/s00239-018-9828-x
PMCID: PMC5846835

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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