Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Newfound association between MDC1 functional polymorphism and lung cancer risk in Chinese.

PloS one - 1 Jan 2014

Wang Bo, Zhang Lisha, Qiu Fuman, Fang Wenxiang, Deng Jieqiong, Zhou Yifeng, Lu Jiachun, Yang Lei

Abstract excerpt

Mediator of DNA damage checkpoint protein 1 (MDC1) plays an early and core role in Double-Strand Break Repair (DDR) and ataxia telangiectasia-mutated (ATM) mediated response to DNA double-strand breaks (DSBs), and thus involves the pathogenesis of several DNA damage-related diseases such as cancer. We hypothesized that the single nucleotide polymorphisms (SNPs) of MDC1 which have potencies on affecting MDC1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Lung Neoplasms

Share to Nuclear Proteins

Share to Polymorphism, Single Nucleotide

Share to Trans-Activators

Source

Open in PubMed Open full text

Identifiers

PMID: 25198518
DOI: 10.1371/journal.pone.0106794
PMCID: PMC4157800

Genes

MDC1
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Newfound association between MDC1 functional polymorphism and lung cancer risk in Chinese.PMID 25198518Read ↗

Prediction of deleterious non-synonymous SNPs of human MDC1 gene: an in silico approach.Semantic proximity Read ↗

The association of c.1471G>A genetic polymorphism in XRCC1 gene with lung cancer susceptibility in Chinese Han population.Semantic proximity Read ↗

SNP rs17079281 decreases lung cancer risk through creating an YY1-binding site to suppress DCBLD1 expression.Semantic proximity Read ↗

Methyl-CpG binding domain 1 gene polymorphisms and lung cancer risk in a Chinese population.Semantic proximity Read ↗

rs66651343 and rs12909095 confer lung cancer risk by regulating CCNDBP1 expression.Semantic proximity Read ↗

Methyl-CpG binding domain 1 gene polymorphisms and risk of primary lung cancer.Semantic proximity Read ↗

Polymorphisms and rare variants identified by next-generation sequencing confer risk for lung cancer in han Chinese population.Semantic proximity Read ↗

Functional defects of cancer-associated MDC1 mutations in DNA damage repair.Semantic proximity Read ↗

DNA double-strand break repair capacity and its pathway gene variants predict the risk and prognosis of lung cancer.Semantic proximity Read ↗

Roles for MDC1 in cancer development and treatment.Semantic proximity Read ↗

Influence of CMTM8 polymorphisms on Lung Cancer Susceptibility in the Chinese Han PopulationSemantic proximity Read ↗

Genetic variant in CLPTM1L confers reduced risk of lung cancer: a replication study in Chinese and a meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.