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DNA double-strand break repair capacity and its pathway gene variants predict the risk and prognosis of lung cancer.

Lung cancer (Amsterdam, Netherlands) - 1 Jun 2024

Peng Li, Lidan Hao, Cuicui Zhang, Zhe Zhang, Sen Yang, Xuan Wu, Ganghua Li, Chao Zhang, Zhensheng Liu, Qiming Wang

Abstract excerpt

OBJECTIVES: This study aims to investigate the association between DNA double-strand breaks (DSBs) repair capacity, variations in DSBs-related genes, and the occurrence and prognosis of lung cancer in the Chinese population. METHODS: Peripheral blood mononuclear cells (PBMC) were collected from 98 lung cancer patients and 60 healthy individuals. The individual DSBs repair capacity was assessed by measuring...

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Identifiers

PMID: 38805902
DOI: 10.1016/j.lungcan.2024.107831

Genes

BRCA1
FOXO3
H2AX
LIG4

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