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Article

DNA gag/adenovirus type 5 (Ad5) gag and Ad5 gag/Ad5 gag vaccines induce distinct T-cell response profiles.

Journal of virology - 1 Aug 2008

Cox Kara S, Clair James H, Prokop Michael T, Sykes Kara J, Dubey Sheri A, Shiver John W, Robertson Michael N, Casimiro Danilo R

Abstract excerpt

Results from Merck's phase II adenovirus type 5 (Ad5) gag/pol/nef test-of-concept trial showed that the vaccine lacked efficacy against human immunodeficiency virus (HIV) infection in a high-risk population. Among the many questions to be explored following this outcome are whether (i) the Ad5 vaccine induced the quality of T-cell responses necessary for efficacy and (ii) the lack of efficacy in the Ad5 vaccine...

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Identifiers

PMID: 18524823
DOI: 10.1128/JVI.00620-08
PMCID: PMC2519591

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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