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Neutralizing Antibodies and CD8 <sup>+</sup> T Lymphocytes both Contribute to Immunity to Adenovirus Serotype 5 Vaccine Vectors

27 Feb 2004

Abstract excerpt

The high prevalence of preexisting immunity to adenovirus serotype 5 (Ad5) in human populations will likely limit the immunogenicity and clinical utility of recombinant Ad5 vector-based vaccines for human immunodeficiency virus type 1 and other pathogens. Ad5-specific neutralizing antibodies (NAbs) are thought to contribute substantially to anti-Ad5 immunity, but the potential importance of Ad5-specific T...

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PMID: 14990686
DOI: 10.1128/jvi.78.6.2666-2673.2004

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