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New Insights on Adenovirus as Vaccine Vectors

9 Jun 2009

Abstract excerpt

Adenovirus (Ad) vectors were initially developed for treatment of genetic diseases. Their usefulness for permanent gene replacement was limited by their high immunogenicity, which resulted in rapid elimination of transduced cells through induction of T and B cells to antigens of Ad and the transgene product. The very trait that excluded their use for sustained treatment of genetic diseases made them highly...

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PMID: 19513019
DOI: 10.1038/mt.2009.130

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