Article
Vaccination with Ad5 vectors expands Ad5-specific CD8 T cells without altering memory phenotype or functionality.
PloS one - 22 Dec 2010
Hutnick Natalie A, Carnathan Diane G, Dubey Sheri A, Cox Kara S, Kierstead Lisa, Makadonas George, Ratcliffe Sarah J, Lasaro Marcio O, Robertson Michael N, Casimiro Danilo R, Ertl Hildegund C J, Betts Michael R
Abstract excerpt
BACKGROUND: Adenoviral (Ad) vaccine vectors represent both a vehicle to present a novel antigen to the immune system as well as restimulation of immune responses against the Ad vector itself. To what degree Ad-specific CD8(+) T cells are restimulated by Ad vector vaccination is unclear, although such knowledge would be important as vector-specific CD8(+) T cell expansion could potentially further limit Ad vaccine...
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