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Article

Functional characterization of dosage-dependent lethal mutation of ubiquitin in Saccharomyces cerevisiae.

FEMS yeast research - 1 Nov 2014

Doshi Ankita, Mishra Pradeep, Sharma Mrinal, Prabha C Ratna

Abstract excerpt

Ubiquitin is a eukaryotic protein with 96% sequence conservation from yeast to human. Ubiquitin plays a central role in protein homeostasis and regulation of protein function. We have reported on the generation of variants of ubiquitin by in vitro evolution in Saccharomyces cerevisiae to advance our understanding of the role of the invariant amino acid residues of ubiquitin in relation to its function. One of the...

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PMID: 25195938
DOI: 10.1111/1567-1364.12209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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