Article
Distinct functional surface regions on ubiquitin.
The Journal of biological chemistry - 10 Aug 2001
Sloper-Mould K E, Jemc J C, Pickart C M, Hicke L
Abstract excerpt
The characterized functions of the highly conserved polypeptide ubiquitin are to target proteins for proteasome degradation or endocytosis. The formation of a polyubiquitin chain of at least four units is required for efficient proteasome binding. By contrast, monoubiquitin serves as a signal for the endocytosis of plasma membrane proteins. We have defined surface residues that are important for ubiquitin's vital...
Topics
- Alanine
- Amino Acid Sequence
- Binding Sites
- Cell Division
- Cysteine Endopeptidases
- Endocytosis
- Isoleucine
- Mating Factor
- Models, Molecular
- Molecular Sequence Data
- Multienzyme Complexes
- Mutagenesis, Site-Directed
- Mutation
- Peptides
- Phenylalanine