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Article

Distinct functional surface regions on ubiquitin.

The Journal of biological chemistry - 10 Aug 2001

Sloper-Mould K E, Jemc J C, Pickart C M, Hicke L

Abstract excerpt

The characterized functions of the highly conserved polypeptide ubiquitin are to target proteins for proteasome degradation or endocytosis. The formation of a polyubiquitin chain of at least four units is required for efficient proteasome binding. By contrast, monoubiquitin serves as a signal for the endocytosis of plasma membrane proteins. We have defined surface residues that are important for ubiquitin's vital...

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PMID: 11399765
DOI: 10.1074/jbc.M103248200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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