Article
Structural changes induced by L50P and I61T single mutations of ubiquitin affect cell cycle progression while impairing its regulatory and degradative functions in Saccharomyces cerevisiae.
International journal of biological macromolecules - 1 Jun 2017
Doshi Ankita, Sharma Mrinal, Prabha C Ratna
Abstract excerpt
Posttranslational conjugation of ubiquitin to proteins either regulates their function directly or concentration through ubiquitination dependent degradation. High degree of conservation of ubiquitin's sequence implies structural and functional importance of the conserved residues. Ubiquitin gene of Saccharomyces cerevisiae was evolved in vitro by us to study the significance of conserved residues. Present study...
Topics
- Anti-Bacterial Agents
- CDC28 Protein Kinase, S cerevisiae
- Cell Cycle
- Heat-Shock Response
- Mitogen-Activated Protein Kinases
- Mutation
- Proteolysis
- RNA, Messenger
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins