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Probing the effects of double mutations on the versatile protein ubiquitin in Saccharomyces cerevisiae.

International journal of biological macromolecules - 15 May 2021

Sharma Mrinal, Yadav Prranshu, Doshi Ankita, Brahmbhatt Hemang D, Prabha C Ratna

Abstract excerpt

Ubiquitin is an indispensable protein of eukaryotic origin with an extraordinarily high degree of sequence conservation. It is used to tag proteins post-translationally and the process of ubiquitination regulates the activity of the modified proteins or drives them for degradation. Double mutations produce varied effects in proteins, depending on the structural relationship of the mutated residues, their role in...

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PMID: 33662424
DOI: 10.1016/j.ijbiomac.2021.02.208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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