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Article

Hypomethylation of<i>IL10</i>and<i>IL13</i>Promoters in CD4<sup>+</sup>T Cells of Patients with Systemic Lupus Erythematosus

1 Jan 2010

Abstract excerpt

Interleukin- (IL-)10 and IL-13 play important roles in Th2 cell differentiation and production of autoantibodies in patients with (SLE). However, the mechanisms leading to IL10 and IL13 overexpression in SLE patients are not well understood. In this study, we confirm that the levels of both IL10 and IL13 mRNA in CD4+ T cells and of serum IL10 and IL13 proteins are increased in SLE patients. We show that the DNA...

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Identifiers

PMID: 20589076
DOI: 10.1155/2010/931018

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