Article
Autoimmunity-Associated SNP rs3024505 Disrupts STAT3 Binding in B Cells, Leading to IL10 Dysregulation.
International journal of molecular sciences - 23 Sept 2024
Uvarova Aksinya N, Zheremyan Elina A, Ustiugova Alina S, Murashko Matvey M, Bogomolova Elvina A, Demin Denis E, Stasevich Ekaterina M, Kuprash Dmitry V, Korneev Kirill V
Abstract excerpt
Interleukin 10 (IL10) is a major anti-inflammatory cytokine that acts as a master regulator of the immune response. A single nucleotide polymorphism rs3024505(C/T), located downstream of the IL10 gene, is associated with several aggressive inflammatory diseases, including systemic lupus erythematosus, Sjögren's syndrome, Crohn's disease, and ulcerative colitis. In such autoimmune pathologies, IL10-producing B...
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