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From deep sequencing to actual clones

1 Sept 2014

Abstract excerpt

The application of deep sequencing to in vitro display technologies has been invaluable for the straightforward analysis of enriched clones. After sequencing in vitro selected populations, clones are binned into identical or similar groups and ordered by abundance, allowing identification of those that are most enriched. However, the greatest strength of deep sequencing is also its greatest weakness: clones are...

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PMID: 25183780
DOI: 10.1093/protein/gzu032

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