Article
Phenotype-information-phenotype cycle for deconvolution of combinatorial antibody libraries selected against complex systems.
Proceedings of the National Academy of Sciences of the United States of America - 16 Aug 2011
Zhang Hongkai, Torkamani Ali, Jones Teresa M, Ruiz Diana I, Pons Jaume, Lerner Richard A
Abstract excerpt
Use of large combinatorial antibody libraries and next-generation sequencing of nucleic acids are two of the most powerful methods in modern molecular biology. The libraries are screened using the principles of evolutionary selection, albeit in real time, to enrich for members with a particular phenotype. This selective process necessarily results in the loss of information about less-fit molecules. On the other...
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