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By-passing in vitro screening—next generation sequencing technologies applied to antibody display and in silico candidate selection

15 Sept 2010

Abstract excerpt

In recent years, unprecedented DNA sequencing capacity provided by next generation sequencing (NGS) has revolutionized genomic research. Combining the Illumina sequencing platform and a scFv library designed to confine diversity to both CDR3, >1.9 × 10(7) sequences have been generated. This approach allowed for in depth analysis of the library's diversity, provided sequence information on virtually all scFv...

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PMID: 20846958
DOI: 10.1093/nar/gkq789

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