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Article

An analysis of skeletal development in osteoblast-specific and chondrocyte-specific runt-related transcription factor-2 (Runx2) knockout mice.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Oct 2013

Takarada Takeshi, Hinoi Eiichi, Nakazato Ryota, Ochi Hiroki, Xu Cheng, Tsuchikane Azusa, Takeda Shu, Karsenty Gerard, Abe Takaya, Kiyonari Hiroshi, Yoneda Yukio

Abstract excerpt

Global gene deletion studies in mice and humans have established the pivotal role of runt related transcription factor-2 (Runx2) in both intramembranous and endochondral ossification processes during skeletogenesis. In this study, we for the first time generated mice carrying a conditional Runx2 allele with exon 4, which encodes the Runt domain, flanked by loxP sites. These mice were crossed with...

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PMID: 23553905
DOI: 10.1002/jbmr.1945

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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An analysis of skeletal development in osteoblast-specific and chondrocyte-specific runt-related transcription factor-2 (Runx2) knockout mice.PMID 23553905Read ↗

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