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Article

β1 integrins mediate the BMP2 dependent transcriptional control of osteoblast differentiation and osteogenesis

20 Apr 2018

Abstract excerpt

Osteoblast differentiation is a highly regulated process that requires coordinated information from both soluble factors and the extracellular matrix. Among these extracellular stimuli, chemical and physical properties of the matrix are sensed through cell surface receptors such as integrins and transmitted into the nucleus to drive specific gene expression. Here, we showed that the conditional deletion of β1...

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PMID: 29677202
DOI: 10.1371/journal.pone.0196021

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