Article

PAC: Highly accurate quantification of allelic gene expression for population and disease genetics

2021-07-14

Abstract excerpt

Analysis of allele-specific gene expression (ASE) is a powerful approach for studying gene regulation. However, detection of ASE events relies on accurate alignment of RNA-sequencing reads, where challenges still remain. We have developed PAC, a method that combines multiple steps to improve the quantification of allelic reads, including personalised (i.e. diploid) read alignment with improved allocation of multi-...

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Literature Corpus work: b3884c03-8d4b-51b2-bfae-c7a1c6409921
DOI: 10.1101/2021.07.13.452202

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