Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of g protein-coupled receptor kinase 1 (Grk1) overexpression on rod photoreceptor cell viability.

Investigative ophthalmology & visual science - 1 Mar 2010

Whitcomb Tiffany, Sakurai Keisuke, Brown Bruce M, Young Joyce E, Sheflin Lowell, Dlugos Cynthia, Craft Cheryl M, Kefalov Vladimir J, Khani Shahrokh C

Abstract excerpt

PURPOSE: Photoreceptor rhodopsin kinase (Rk, G protein-dependent receptor kinase 1 [Grk1]) phosphorylates light-activated opsins and channels them into an inactive complex with visual arrestins. Grk1 deficiency leads to human retinopathy and heightened susceptibility to light-induced photoreceptor cell death in the mouse. The goal of this study was to determine whether excess Grk1 activity is protective against...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Artificial, Bacterial
Share to Electrophysiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorescent Antibody Technique, Indirect

Share to In Situ Nick-End Labeling

Share to Mice, Inbred C3H

Share to Retinal Degeneration

Share to Retinal Rod Photoreceptor Cells

Share to Rhodopsin

Source

Open in PubMed Open full text

Identifiers

PMID: 19834036
DOI: 10.1167/iovs.09-4499
PMCID: PMC2868427

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of g protein-coupled receptor kinase 1 (Grk1) overexpression on rod photoreceptor cell viability.PMID 19834036Read ↗

Variation in rhodopsin kinase expression alters the dim flash response shut off and the light adaptation in rod photoreceptors.Semantic proximity Read ↗

Grk7 but not Grk1 undergoes cAMP-dependent phosphorylation in zebrafish cone photoreceptors in the dark and mediates recovery of the cone photoresponse in response to forskolinSemantic proximity Read ↗

Induction of the unfolded protein response by constitutive G-protein signaling in rod photoreceptor cells.Semantic proximity Read ↗

Synchronized photoactivation of T4K rhodopsin causes a chromophore-dependent retinal degeneration that is moderated by interaction with phototransduction cascade componentsSemantic proximity Read ↗

Mutant rhodopsin transgene expression on a null background.Semantic proximity Read ↗

The retinal phenotype of Grk1-/- is compromised by a Crb1 rd8 mutation.Semantic proximity Read ↗

Proteasome overload is a common stress factor in multiple forms of inherited retinal degenerationSemantic proximity Read ↗

Targeted inactivation of synaptic HRG4 (UNC119) causes dysfunction in the distal photoreceptor and slow retinal degeneration, revealing a new function.Semantic proximity Read ↗

Light causes phosphorylation of nonactivated visual pigments in intact mouse rod photoreceptor cells.Semantic proximity Read ↗

Altered cAMP levels in retinas from transgenic mice expressing a rhodopsin mutant.Semantic proximity Read ↗

Stable rhodopsin/arrestin complex leads to retinal degeneration in a transgenic mouse model of autosomal dominant retinitis pigmentosa.Semantic proximity Read ↗

Exacerbated response to oxidative stress in the Retinitis Pigmentosa Cerkl mouse model triggers retinal degeneration pathways upon acute light stressSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.