Article
Gene polymorphisms of novel immunotolerant molecule BTLA: distribution of alleles, genotypes and haplotypes in Polish Caucasian population.
Archivum immunologiae et therapiae experimentalis - 1 Feb 2015
Partyka Anna, Woszczyk Dariusz, Strzała Tomasz, Szczepańska Anna, Tomkiewicz Anna, Frydecka Irena, Karabon Lidia
Abstract excerpt
B and T lymphocyte attenuator (BTLA) is one of the members of immunoglobulin superfamily which, like CTLA-4 and PD-1, is involved in down regulation of immune response. Despite the important role of BTLA in maintaining immune homeostasis, relatively little studies were devoted to the relationship of polymorphisms in the gene encoding BTLA with susceptibility to autoimmune disease and cancer. Moreover, all...
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