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Article

Immune Checkpoint Molecules-Inherited Variations as Markers for Cancer Risk.

Frontiers in immunology - 1 Jan 2020

Wagner Marta, Jasek Monika, Karabon Lidia

Abstract excerpt

In recent years, immunotherapy has been revolutionized by a new approach that works by blocking receptors called immune checkpoints (IC). These molecules play a key role in maintaining immune homeostasis, mainly by suppressing the immune response and by preventing its overactivation. Since inhibition of the immune response by IC can be used by cancer to avoid recognition and destruction by immune system, blocking...

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Identifiers

PMID: 33519815
DOI: 10.3389/fimmu.2020.606721
PMCID: PMC7840570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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