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Article

A Functional Variant of SMAD4 Enhances Thoracic Aortic Aneurysm and Dissection Risk through Promoting Smooth Muscle Cell Apoptosis and Proteoglycan Degradation.

EBioMedicine - 1 Jul 2017

Wang Ying, Huang Hao-Yue, Bian Guang-Liang, Yu Yun-Sheng, Ye Wen-Xue, Hua Fei, Chen Yi-Huan, Shen Zhen-Ya

Abstract excerpt

Recent studies indicate important roles for SMAD4 in SMCs proliferation, extracellular matrix maintenance, and blood vessel remodeling. However, the genetic effects of SMAD4 in the pathogenesis of thoracic aortic aneurysm and dissection (TAAD) are still largely unknown. Here we identified a functional variant of SMAD4 which might be involved in the pathological progression of TAAD. Five tagging SNPs of SMAD4 were...

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Share to Aortic Aneurysm, Thoracic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Myocytes, Smooth Muscle

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Source

Open in PubMed Open full text

Identifiers

PMID: 28666732
DOI: 10.1016/j.ebiom.2017.06.022
PMCID: PMC5514432

Genes

SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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