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Article

Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics.

The FEBS journal - 1 Nov 2009

Gillings Annette S, Balmanno Kathryn, Wiggins Ceri M, Johnson Mark, Cook Simon J

Abstract excerpt

The BCL-2 homology domain 3 (BH3)-only protein, B-cell lymphoma 2 interacting mediator of cell death (BIM) is a potent pro-apoptotic protein belonging to the B-cell lymphoma 2 protein family. In recent years, advances in basic biology have provided a clearer picture of how BIM kills cells and how BIM expression and activity are repressed by growth factor signalling pathways, especially the extracellular...

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Identifiers

PMID: 19788418
DOI: 10.1111/j.1742-4658.2009.07329.x

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